LONGITUDINAL MONITORING OF KRAS-MUTATED CIRCULATING TUMOR DNA ENABLES THE PREDICTION OF PROGNOSIS AND THERAPEUTIC RESPONSES IN PATIENTS WITH PANCREATIC CANCER.

BackgroundLiquid biopsies enable the detection of circulating tumor DNA (ctDNA).However, the clinical significance of KRAS-mutated ctDNA for pancreatic cancer has been inconsistent with respect Bread Mix to its prognostic and predictive potential.Methods and findingsA total of 422 blood samples were collected from 78 patients undergoing treatments

Massively parallel sequencing of cell-free, maternal plasma DNA was recently demonstrated to be a safe and effective screening method for fetal chromosomal aneuploidies.Here, we report an improved sequencing method achieving significantly increased throughput and decreased cost Rigs by replacing laborious sequencing library preparation steps with P

Post-earthquake fire is considered as a catastrophic secondary disaster to personal and property safety, especially in complex rail transit station.This is primarily attributed to intricate infrastructure, densely populated floors, and the unrestricted layout of these areas.The aim of this study is to evaluate the evacuation capacity of complex rai

Innovative multifunctional materials that combine structural functionality with other spacecraft subsystem functions have been identified as a key enabling technology for future deep space missions.In this work, we report the structure and performance of multifunctional polymer matrix composites developed for aerospace applications that require bot

Sunflower varieties having plants with armored-layer seeds resulted in a high reduction pca display of seed damage caused by larval feeding of the sunflower moth, Homoeosoma electel-lum (Hulst).Several sunflower lines were significantly more resistant to seed damage when the plants had armored-layer seeds than when the same lines had non-armored-la